Job Description

Job DescriptionSalary: $160,000 - $170,000

About Oxford BioTherapeutics:

Oxford BioTherapeutics (OBT) is a clinical stage oncology company with a pipeline of immuno-oncology and antibody-drug conjugate-based therapies. OBT's IO discovery process provides unique insight into the cancer-immune cell synapse and has identified several novel IO candidates for cancer therapy. Discovery of novel tumor antigens and immune cell surface proteins at OBT is performed using the proprietary Oxford Genome Anatomy Project (OGAP) database. OBT currently has one ADC in phase 1b clinical trials in collaboration with Menarini. OBT is a dynamic, growing, international biotechnology company based in Oxford, UK, and San Jose, CA. For further information, please see .

Purpose of the Role

To be the associate IHC team lead reporting to the Director of IHC, overseeing as required and bringing deep knowledge and experience to the team.

Job Description

We are seeking a motivated, communicative, and detail-oriented Senior or Principal Scientist to join our histopathology lab within the Target Validation Team at our San Jose, CA site. The candidate will report to the Director of IHC and be expected to independently execute histopathology techniques for evaluating tumor and immune cell therapeutic targets, supervise RAs, and coordinate data presentation internally and externally.

This role will support target validation and molecule assessment in our pipeline using immunohistochemistry (IHC), immunofluorescence (IF), in situ hybridization (ISH), microscopy, and digital imaging and analysis. Responsibilities include developing, screening, and validating IHC antibodies, tissue procurement, sample processing, sectioning, and assay development (manual and automated). Knowledge of histology and oncology fundamentals is essential; cell culture and molecular biology experience are desirable.

Training, supervising, and presenting to external parties are key elements of this role.

Main Responsibilities:

• Design, develop, execute, and oversee histopathology procedures including tissue processing, H&E, IHC, ISH, and immunofluorescence staining.
• Use tissue-based assays for patient stratification, prevalence, and expression analysis in normal vs diseased tissues.
• Supervise, mentor, and train less experienced employees.
• Interpret and present data internally and externally on research programs.
• Coordinate with stakeholders on program development and business presentations.

• Plan research activities with input from the IHC Director and stakeholders.

• Develop expertise in target proteins and their expression profiles, especially in oncology.
• Execute tissue experiments, including antibody validation in preclinical models.
• Evaluate new technologies like digital image analysis and deep learning.
• Oversee data analysis and project delivery from CROs.
• Collaborate in a matrixed organization to advance projects into clinical development.
• Act as a technical expert and guide internal teams.

Roles and responsibilities are not limited to those listed above.

Knowledge, Experience, and Skills:

Essential

• PhD with >5 years in histology or Bachelor/Master with >10 years industry experience. MD candidates may also be considered.
• Extensive experience in histology, tissue preparation, sectioning, IHC, ISH, and microscopy.
• Experience with chromogenic and fluorescent staining on various samples.
• Knowledge of antibody discovery and testing for IHC.
• Expertise with microscopy, digital pathology, and image analysis platforms.
• Strong data presentation skills for diverse audiences.
• Experience in project planning, prioritization, and fast-paced environments.
• Ability to train, mentor, and develop others.
• Experience working with service providers and CROs.
• Knowledge of tumor pathology, cancer biology, and immuno-oncology.

Desirable

• Experience in CDx development.
• Tissue culture experience.

Personal Qualities:

• Excellent organization skills and adaptability.
• Collaborative mindset and matrixed environment operation.
• Willingness to represent OBT as an IHC lead.
• Passion for talent growth and cancer treatment contributions.

We prioritize employee health and wellbeing through comprehensive benefits, including health insurance, FSA, insurance plans, 401(k), paid time off, holidays, referral bonuses, annual bonuses, and stock options.

Equal Opportunities Statement

OBT is an equal opportunity employer, prohibiting discrimination based on race, color, religion, sex, national origin, age, disability, or veteran status. We are committed to a healthy, respectful, and inclusive work environment.

Why Join Us

We foster a culture of innovation, responsibility, and commitment. Our team is friendly, collaborative, and hardworking, with mutual trust and respect at our core. We aim to develop groundbreaking cancer therapies through a cooperative and innovative environment.

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